MAP3K4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1282-1286 amino acids of human mitogen-activated protein kinase kinase kinase 4
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mitogen-activated protein kinase kinase kinase 4
Database Link	NP_005913 Entrez Gene 4216 Human UniProt ID Q9Y6R4
Background	The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK); which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation; the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock; UV irradiation; wound stress; and inflammatory factors. This gene encodes a MAPKKK; the MEKK4 protein; also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways; but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1; MAPKKs that activate CSBP2 and JNK; respectively but cannot phosphorylate PRKMK1; an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway; and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.
Synonyms	MAPKKK4; MEKK 4; MEKK4; MTK1; PRO0412
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	GnRH signaling pathway, MAPK signaling pathway

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