DIS3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3.
Formulation	DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DIS3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 105 kDa; Observed: 103 kDa
Gene Name	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Database Link	NP_055768 Entrez Gene 72662 MouseEntrez Gene 306103 RatEntrez Gene 22894 Human UniProt ID Q9Y2L1
Background	DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Synonyms	2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44
Reference Data
Protein Pathways	RNA degradation

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