PCNA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:2,000 - 1:8,000, WB: 1:500 - 1:2,000
Reactivity	Human, Monkey, Dog, Mouse, Bovine, Xenopus, Rat, Chicken, Fish
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human PCNA protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	proliferating cell nuclear antigen
Database Link	NP_002583 Entrez Gene 18538 MouseEntrez Gene 25737 RatEntrez Gene 477166 DogEntrez Gene 718006 MonkeyEntrez Gene 5111 Human UniProt ID P12004
Synonyms	ATLD2
Note	The proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the processibility of DNA polymerase during elongation of the leading strand. PCNA is expressed in the nucleus of all proliferating cells and is pivotal for DNA synthesis and cell cycle progression. In response to DNA damage, PCNA is mono-ubiquitinated and is involved in mismatch-provoked excision. PCNA is a useful marker for DNA synthesis and is highly conserved among most species.
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

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