Syvn1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry: 1:200 - 1:500, Western Blot: 1:1000 - 1:2000, Immunocytochemistry/ Immunofluorescence: 1:500, Knockout Validated, Immunoprecipitation, Immunohistochemistry-Paraffin: 1:200 - 1:500
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an internal portion of the human protein (within residues 300-400). [UniProt Q96PK3]
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	synovial apoptosis inhibitor 1, synoviolin
Database Link	NP_083045 Entrez Gene 74126 Mouse UniProt ID Q9DBY1
Background	HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
Synonyms	HRD1; KIAA1810; MGC40372
Reference Data

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