TSH Receptor (TSHR) Mouse Monoclonal Antibody [Clone ID: 2C11]

Specifications

Product Data
Clone Name	2C11
Applications	ELISA, FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry. ELISA. Immunoprecipitation: 5-10 µg/ml. Western Blot: 5-10 µg/ml. Immunohistochemistry on Paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TSH receptor. Spleen cells from immunised BALB/c mice were fused with cells of the NS1/Ag4.1 mouse myeloma cell line.
Specificity	2C11 recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors. This antibody recognises the mutant TSH receptor known as I167N as well as the wild type molecule.
Formulation	PBS, pH7.2 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroid stimulating hormone receptor
Database Link	Entrez Gene 7253 Human UniProt ID P16473
Background	The thyroid stimulating hormone (TSH) receptor (otherwise known as the thyrotropin receptor) is an important molecule in controlling the growth and function of the normal thyroid.
Synonyms	Thyroid-stimulating hormone receptor, TSH-receptor, TSH-R, LGR3
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.