Integrin alpha 6 (ITGA6) Rat Monoclonal Antibody [Clone ID: NKI-GoH3]

Specifications

Product Data
Clone Name	NKI-GoH3
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control Tissue: Human Tonsil. Immunoprecipitation.
Reactivity	Canine, Human, Monkey, Mouse, Porcine, Sheep
Host	Rat
Clonality	Monoclonal
Immunogen	BALB/c mouse mammary tumour cells. Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line.
Specificity	This antibody recognises the CD49f-antigen, (VLA-6 alpha-chain). This antibody reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In Immunohistology this clone reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor. This clone has been reported to inhibit platelet adhesion to Laminin. (3)
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha 6
Database Link	Entrez Gene 3655 Human UniProt ID P23229
Background	CD49f can form distinct complexes with either the CD29-antigen (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.
Synonyms	Integrin alpha-6, VLA-6, VLA6
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.