CEACAM5 Mouse Monoclonal Antibody [Clone ID: 26/3/13]

Specifications

Product Data
Clone Name	26/3/13
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200. Flow Cytometry: 1.2 µg/106 cells. Immunofluorescence: 1/200. Western blot: 4 µg/ml. Immunohistochemistry on Cryo -Sections: 1-2 µg/106 cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Extracted protein of CEACAM5. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells
Specificity	This antibody recognizes exclusively CECAM5.
Formulation	PBS, pH 7.2 without preservatives State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	carcinoembryonic antigen related cell adhesion molecule 5
Database Link	Entrez Gene 1048 Human UniProt ID P06731
Background	CEACAM5 (CEA-related cell adhesion molecule 5, CEA) belongs to the carcinoembryonic antigen (CEA) gene family (1,2). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 180,000-200,000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cell of the tongue, esophagus and cervix. CEACAM5 is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas (3). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).
Synonyms	CEA, Carcinoembryonic antigen
Reference Data

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