XPB (ERCC3) Mouse Monoclonal Antibody [Clone ID: OTI6H8]

Specifications

Product Data
Clone Name	OTI6H8
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 191-436 of human ERCC3 (NP_000113) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	89.1 kDa
Gene Name	ERCC excision repair 3, TFIIH core complex helicase subunit
Database Link	NP_000113 Entrez Gene 13872 MouseEntrez Gene 291703 RatEntrez Gene 2071 Human UniProt ID P19447
Background	ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]
Synonyms	BTF2; GTF2H; RAD25; Ssl2; TFIIH; TTD2; XPB
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Nucleotide excision repair

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