TNFRSF1B (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/50.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from C-terminal of Mouse TNF-R2
Specificity	This antibody recognizes the C-term of TNFRSF1B / TNFR2.
Formulation	10 mM PBS, pH 7.4, BSA, 0.09% sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	tumor necrosis factor receptor superfamily member 1B
Database Link	Entrez Gene 21938 MouseEntrez Gene 156767 RatEntrez Gene 7133 Human UniProt ID P20333
Background	TNFR2 is a 75 kD transmembrane glycoprotein that also exists as a secreted protein. TNF receptors self assemble through a distinct functional extracellular domain termed PLAD in the absence of ligand. Efficient TNFA binding depends on receptor self assembly. TNFR2 has been shown to be responsible for stimulation of activated T lymphocytes by TNFalpha.
Synonyms	Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), Cytokine-cytokine receptor interaction

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