Trpv1 (105-115) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:100,000 for detection of Kchip1 peptide (QTKQRRPSKDK) coated on ELISA plate. Western blot: Dilute approx. 1:5,000 to detect the 95kDa TRPV1 in mouse brain tissue extract.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to the amino acid sequence 105-115 of mouse TRPV1, conjugated with KLH
Specificity	This antibody is reactive to the 95kDa TRPV1 in mouse brain tissue extract and other species with consensus TRPV1 sequence (GEKPPRLYDRR).
Formulation	0.01M PBS, pH 7.4 State: Azide Free State: Lyophilized Ig fraction
Reconstitution Method	Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification	Protein G affinity
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	transient receptor potential cation channel, subfamily V, member 1
Database Link	Entrez Gene 193034 Mouse UniProt ID Q704Y3
Background	Mouse transient receptor potential cation channel V1 (TRPV1) is a nociceptor which is activated by noxious stimuli such as high temprature (above 43o C), acidic PH, and pungent chemical such as vanilloid, the “hot” componeunt of chili peppers. Members of the TPV family are capble of polymodal activation and have a similar tetramer structure. There are transmembrane regions with pore forming domains on the monomers. In chronic pain condition, normally innocuous stimuli is converted as noxious signaling. It is believed that TRPV1 is one of the contributors of this wrong transduction. TRPV1 has emerged as a target for pain medication.
Synonyms	VR1, Capsaicin receptor, OTRPC1
Reference Data

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