c Kit (KIT) Rabbit Polyclonal Antibody

CAT#: AP09513PU-N

c Kit (KIT) rabbit polyclonal antibody, Aff - Purified

Size: 50 ul 100 ul



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CNY 2,250.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommend Dilution Immunohistochemistry: 1/50-1/100.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen peptide sequence around amino acids 934~938 (H-I-Y-S-N) derived from Human c-kit.
Specificity c-kit Antibody detects endogenous levels of total c-kit protein.
Formulation Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity Chromatography using epitope-specific peptide
Conjugation Unconjugated
Storage Condition Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Gene Name KIT proto-oncogene receptor tyrosine kinase
Background c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
Synonyms SCFR, KIT
Note Molecular Weight: 145 kDa
Reference Data
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Protein Kinase, Stem cell - Pluripotency, Transmembrane
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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