ACOX1 Mouse Monoclonal Antibody [Clone ID: 153CT43.1.1]

Specifications

Product Data
Clone Name	153CT43.1.1
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/100-1/500. Immunofluorescence: 1/10-1/50.  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	ACOX1 recombinant protein.
Specificity	This antibody recognizes Human ACOX1.  Other species not tested.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography, followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	acyl-CoA oxidase 1, palmitoyl
Database Link	Entrez Gene 51 Human UniProt ID Q15067
Background	ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids.  Function: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. Cellular Location: Peroxisome.  Tissue Location: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.
Synonyms	AOX, Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidase
Reference Data

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