Bst1 Rat Monoclonal Antibody [Clone ID: KT157]

Specifications

Product Data
Clone Name	KT157
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	T cell hybridoma J774. Donor: Balb/c mouse spleen cells. Fusion Partner: NSO Mouse Myelom a Partner.
Specificity	This Monoclonal Antibody reacts with Mouse CD157 receptor. Other species not tested.
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	bone marrow stromal cell antigen 1
Database Link	Entrez Gene 12182 Mouse UniProt ID Q64277
Background	CD157 also known as BP-3 Alloantigen or Bone marrow Stromal cell antigen-1 (BST-1), is a 38-48 KDa differentially glycosylated glycosylphosphatidylinositol (GPI) anchored cell surface glycoprotein. CD157, like CD38 belongs to a family of genetically related pleiotropic ectoenzymes. The CD157 antigen is expressed on thymocytes, bone marrow B cells, neutrophils, macrophages, stromal cells, intestinal epithelial cells, the collecting tubules of the kidney and reticular cells in lymph nodes. The CD157 receptor has ADP ribosyl cyclase and cyclic ADP ribose hydrolase biochemical activities. Studies show CD157 is a receptor that induces reorganization of the cytoskeleton and significant changes in cell shape. CD157 is also a mediator of neutrophil adhesion and migration. Signals mediated by CD157 act through modulation of cytosolic [Ca2+]. CD157 is also involved in cellular adhesion to the extracellular matrix.
Synonyms	cADPr hydrolase 2, BST-1
Reference Data

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