IL2 Receptor alpha (IL2RA) Mouse Monoclonal Antibody [Clone ID: B-F2]

Specifications

Product Data
Clone Name	B-F2
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood Immunohistochemistry on paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PHA activated T cells
Specificity	Recognises the Interleukin 2 Receptor a chain (IL-2 Ra), a 55 kDa protein
Formulation	Phosphate-buffered saline containing 1 % BSA as stabilizer and 0.09 % sodium azide as preservative State: Purified State: Liquid purfied Ig fraction
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 2 receptor subunit alpha
Database Link	Entrez Gene 3559 Human UniProt ID P01589
Background	Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Synonyms	Interleukin-2 receptor alpha chain, IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Jak-STAT signaling pathway

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