beta Catenin (CTNNB1) Mouse Monoclonal Antibody [Clone ID: 9F2]

Specifications

Product Data
Clone Name	9F2
Applications	FC, IF, IP, WB
Recommend Dilution	Flow cytometry. Immunoflourescence (cells fixed in paraformaldehyde): The typical starting working dilution is 1:10. Immunoprecipitation (cells fixed in paraformaldehyde). Western blot (cells fixed in paraformaldehyde): The typical starting working dilution is 1:10.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody detects Beta-Catenin.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	catenin beta 1
Database Link	Entrez Gene 1499 Human UniProt ID P35222
Background	Beta-catenin belongs together with alpha- and gamma-catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Beta-catenin is highly homologous to gamma-catenin (plakoglobin) although its function differs from that of plakoglobin. Whereas plakoglobin has been found to suppress tumorigenicity, beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression.
Synonyms	CTNNB1, CTNNB, Beta-catenin
Reference Data

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