Cd4 Mouse Monoclonal Antibody [Clone ID: 15-8A2]

Specifications

Product Data
Clone Name	15-8A2
Applications	IHC
Recommend Dilution	Immunohistochemistry on frozen sections (starting working dilution is 1:100). Flow cytometry (starting working dilution is 1:10).
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	WAG/Rij spleen cells
Specificity	This antibody recognizes rat CD4 antigen (MW 52 kDa) and is reactive with all common inbred strains.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.01% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C.
Gene Name	Cd4 molecule
Database Link	Entrez Gene 24932 Rat UniProt ID P05540
Background	CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.
Synonyms	T-cell surface antigen T4/Leu-3
Reference Data

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