HSP90AB1 Mouse Monoclonal Antibody [Clone ID: MBH90B]

Specifications

Product Data
Clone Name	MBH90B
Applications	IF, IP, WB
Recommend Dilution	Immunoprecipitation: 1 μg/ml. Western blot: 1 μg/ml. Immunocytochemistry: 1 μg/ml. This clone has been desribe to work in Immunohistochemistry on Paraffin Sections.
Reactivity	Bovine, Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide within N-terminal part of human Hsp90
Specificity	This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90 beta an ubiquitously expressed protein with calculated Mw of 83.3 kDa, however, migrating as a 90 kDa band under reducing SDS-PAGE conditions.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	heat shock protein 90kDa alpha family class B member 1
Database Link	Entrez Gene 15516 MouseEntrez Gene 3326 Human UniProt ID P08238
Background	Hsp90 beta (heat shock protein 90 beta) is a constitutively expressed isoform of Hsp90, one of the most abundant chaperones in the cytosol of eukaryotic cells. Hsp90 interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis.
Synonyms	HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84 kDa, HSP84
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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