Dystrophin (DMD) Mouse Monoclonal Antibody [Clone ID: DYS-48]

Specifications

Product Data
Clone Name	DYS-48
Applications	IHC, WB
Recommend Dilution	Western Blot: 1-2 μg/ml. Immunohistochemistry on Paraffin Sections: 2-4 μg/ml (by Heat).
Reactivity	Human, Mouse, Rat, Chicken, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human dystrophin fragment.
Specificity	This antibody reacts to Dystrophin.
Formulation	1.2% Sodium Acetate, with 2 mg BSA and 0.01 mg Sodium Azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS
Concentration	0.1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	dystrophin
Database Link	Entrez Gene 13405 MouseEntrez Gene 24907 RatEntrez Gene 1756 Human UniProt ID P11532
Background	Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain.over expression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.
Synonyms	BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; dystrophin
Reference Data
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis

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