HSP70-1A (HSPA1A) Mouse Monoclonal Antibody [Clone ID: 4E7]

Specifications

Product Data
Clone Name	4E7
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1:1,000 - 1:2,000). Immunohistochemistry (1:100 - 1:200).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Hsp70 (1-641 aa) purified from E. coli
Specificity	The antibody recognizes human Hsp70. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	heat shock protein family A (Hsp70) member 1A
Database Link	Entrez Gene 3303 Human UniProt ID P0DMV8
Background	Hsp70 is a human heat shock protein. Hsp70 is an important part of the cell's machinery for protein folding, and help to protect cells from stress. In most species, there are many proteins that belong to the hsp70 family. Some of these are only expressed under stress conditions, while some are present in cells under normal growth conditions and are not heat-inducible. Hsp70 can be found in different cellular compartments (nuclear, cytosolic, mitochondrial, endoplasmic reticulum, etc...), and the chaperone function of hsp70 is required for protection against stress-induced apoptosis.
Synonyms	HSP70.1, HSP70-1/HSP70-2, HSPA1A, HSPA1B, HSPA1
Reference Data
Protein Pathways	Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Prion diseases, Spliceosome

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