Complement factor B (CFB) (Bb Fragment) Mouse Monoclonal Antibody [Clone ID: 10-09]

Specifications

Product Data
Clone Name	10-09
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA: This antibody binds to both the Bb fragment and complement factor B so is not suitable for all ELISA applications. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptocial glomerlulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human factor B
Specificity	This antibody recognises the Bb fragment of 90 kDa complement factor B, present in blood serum.
Formulation	Borate buffered saline containing 0.09% Sodium Azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor B
Database Link	Entrez Gene 629 Human UniProt ID P00751
Background	C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
Synonyms	Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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