活动过滤器
优化搜索结果
Target Symbol
- BRCA1 (432)
- BTK (325)
- GLUCOKINASE (296)
- MENIN (296)
- BRCA2 (288)
- MLH1 (287)
- TUBERIN (264)
- MSH2 (240)
- IFNG (230)
- P53 (227)
- RET (213)
- FGFR1 (177)
- PDE9A (176)
- NOTCH3 (172)
- BDNF (171)
- DISC1 (165)
- VEGFA (161)
- CREM (159)
- NF2 (159)
- ALPHA 1 ANTITRYPSIN (150)
- NRG1 (150)
- CONSTITUTIVE ANDROSTANE RECEPTOR (139)
- MORTALITY FACTOR 4 LIKE 2 (135)
- NDRG2 (133)
- BIN1 (126)
- UBE2D3 (121)
- G PROTEIN ALPHA S (120)
- WILMS TUMOR PROTEIN (119)
- CTNND1 (117)
- IL10 (116)
- DYSTROBREVIN ALPHA (114)
- EMA (113)
- IRF5 (113)
- MU OPIOID RECEPTOR (113)
- DYSTROPHIN (109)
- EGFR (109)
- MSH6 (109)
- NCALD (109)
- RIBONUCLEASE INHIBITOR (107)
- ST3GAL3 (107)
- CACNA1G (106)
- LKB1 (104)
- PLAGL1 (104)
- TGIF (103)
- FGF1 (102)
- IL32 (102)
- BETA CATENIN (101)
- HMGA1 (101)
- MYOSIN (101)
- TPM1 (101)
- CD46 (100)
- FHL1 (100)
- PQBP1 (100)
- SSH3BP1 (99)
- SYNTABULIN (99)
- ASPARTATE BETA HYDROXYLASE (98)
- SYTL2 (98)
- UBE2V1 (97)
- ALKALINE PHOSPHATASE (96)
- APC11 (96)
- HNF 4 ALPHA (94)
- OSBPL9 (94)
- PCBP2 (94)
- NAT1 (93)
- PML PROTEIN (93)
- MEIS2 (92)
- MTH1 (92)
- RUNX1T1 (92)
- TCF7L2 (91)
- ATAXIN 3 (90)
- FGFR2 (90)
- HFE (90)
- MAX (90)
- UTY (90)
- CAMK2B (88)
- CPNE1 (88)
- FH (88)
- GM CSF RECEPTOR ALPHA (88)
- IKZF3 (88)
- MBNL1 (88)
- RGS3 (88)
- AURORA A (87)
- CD1E (87)
- P38 (87)
- CD59 (86)
- GPR56 (86)
- HNRNP F (86)
- IKAROS (86)
- PRKAR1B (86)
- ESTROGEN RELATED RECEPTOR GAMMA (85)
- PPP2R2B (85)
- AMYLOID PRECURSOR PROTEIN (84)
- RAD17 (84)
- TAU (84)
- ZFYVE27 (84)
- CACNA1C (83)
- CAMKK2 (83)
- CD44 (83)
- CHRM2 (83)
- GLUCOCORTICOID RECEPTOR (83)
Reactivities
Applications
Expression Hosts
Lentivirus
Tags
- Myc-DDK (82034)
- C-Myc/DDK (77343)
- Tag Free (45223)
- TurboGFP (38911)
- mGFP (38899)
- C-MYC/DDK (19716)
- N-His (2740)
- C-His (1992)
- N-GST and C-His (441)
- C-Fc (259)
- C-DDK (195)
- C-6His (160)
- N-GST and C-HIS (150)
- C-DDK/His (102)
- N-GST (93)
- DDK-His (76)
- His-tag (66)
- N-His-ABP (Albumin-Binding Protein) (52)
- C-HIS (45)
- C-Fc&His (44)
- C-Human Fc (44)
- N-His&C-His (42)
- C-mFc (41)
- C-6His-Avi (35)
- C-Mouse Fc and 6×His (30)
- His-Tag (30)
- N-6His (27)
- N-T7&C-His (24)
- C-8His (22)
- C-Mouse Fc (21)
- N-Trx&His (20)
- N-His-Trx (18)
- C-Fc-Avi (16)
- C-hFc (16)
- C-6×His (15)
- C-Avi-6His (14)
- C-Human Fc and 6×His (14)
- N-GST, C-His (13)
- N-Fc (10)
- N-His&SUMO (9)
- C-10His (7)
- C-Avi&6His (7)
- Tag-free (7)
- C- 6×His (6)
- hIgG-Tag (6)
- N-Avi (5)
- N-HIS (5)
- N-His PDCD1(Pro21-Val170) (5)
- N-Mouse Fc and C-6×His (5)
- C-6xHis (4)
- N-GST&His (4)
- N-His&T7 (4)
- N-His-GST (4)
- N-His/DDK (4)
- N-Trx (4)
- C-Fc/His (3)
- C-hFc&His (3)
- N-8His (3)
- hIgG-His-Tag (3)
- C-Flag (2)
- C-HUMAN (2)
- C-Myc-DDK (2)
- N-6His-Avi (2)
- N-DDK (2)
- N-His&Flag (2)
- N-His-PDCD1(Pro21-Val170) (2)
- N-Human Fc (2)
- N-mFc (2)
- N-terminal His (2)
- N-terminal His-PDCD1(Pro21-Val170) tag (2)
- C-6xHis/AVI (1)
- C-AVI (1)
- C-AVI&His (1)
- C-AVI-PLUS (1)
- C-Avi (1)
- C-Avi-His (1)
- C-DDK-His (1)
- C-DDK/10xHis (1)
- C-DDK/6xHis (1)
- C-FC (1)
- C-FC-6HIS&C-FC-Flag (1)
- C-Fc-Flag&C-Fc-6His (1)
- C-Flag,C-6His (1)
- C-GST (1)
- C-HIS/C (1)
- C-HIS/DDK (1)
- C-His&AVI (1)
- C-His&HA&AVI (1)
- C-His/DDK (1)
- C-Human Fc, Avi (1)
- C-Human Fc-Avi (1)
- C-hIgG1 Fc (1)
- C-hIgG2 Fc (1)
- C-hIgG4 Fc (1)
- C-hIgG4P Fc (1)
- C-mFC (1)
- C-mIgG2a Fc (1)
- C-mIgG2aFc (1)
- C-terminal DDK (1)
- C-terminal His (1)
- N-10His-Flag (1)
- N-6His-FLAG (1)
- N-6His-Flag (1)
- N-8His&N-FLAG (1)
- N-8His-Flag (1)
- N-AVI (1)
- N-Avi&6His (1)
- N-DDK/His (1)
- N-FC (1)
- N-FLAG (1)
- N-FUSION (1)
- N-Fc-FLAG (1)
- N-Flag&C-His (1)
- N-Flag&His (1)
- N-GFP (1)
- N-GST(CKM) and N-His(CKB) (1)
- N-GST/C-His (1)
- N-Mouse Fc (1)
- N-T7 (1)
- N-TRX (1)
- N-TRXA (1)
- N-Trx-His (1)
- N-hFc (1)
- No (1)
- Tag free (1)
Vectors
- pCMV6-Entry (61012)
- pCMV6-AC-GFP (38955)
- pLenti-C-Myc-DDK-P2A-Puro (28680)
- pLenti-C-mGFP-P2A-Puro (28611)
- pRS (20309)
- pGFP-C-shLenti (20254)
- EF1a-GFP-P2A-Puro (19104)
- pCMV6-XL5 (11549)
- pLenti-C-Myc-DDK (10560)
- pLenti-C-mGFP (10289)
- pCMV6-XL4 (5167)
- pCMV6-AC (3791)
- pCMVMIR (1829)
- pGFP-V-RS (1369)
- RFP-BSD (1103)
- Luciferase-Puro (1102)
- mBFP-Neo (1102)
- GFP-puro (1101)
- pRFP-C-RS (932)
- pCMV6-XL6 (791)
- PCMV6-Neo (247)
- pCMV6-AC-Myc-DDK (132)
- pCMV6-XL5-DDK-His (76)
- pCMV6-AN-Myc-DDK (27)
- pRMT-tGFP, Promoter-less GFP Reporter Vector (3)
- pCMV6-Entry2 (1)
Reporters
Conjugates
Mutants
Assay Types
Brands
QC Levels
Families
- Druggable Genome (112840)
- Transmembrane (64833)
- WB (40474)
- Transcription Factors (29097)
- Secreted Protein (19133)
- Protein Kinase (10493)
- Protease (6779)
- ES Cell Differentiation/IPS (6510)
- Stem cell - Pluripotency (5725)
- GPCR (3809)
- Phosphatase (2947)
- Ion Channels: Other (2002)
- Adult stem cells (1496)
- Nuclear Hormone Receptor (1323)
- Embryonic stem cells (1217)
- Ion Channels: Potassium (966)
- Cancer stem cells (742)
- P450 (699)
- Induced pluripotent stem cells (671)
- Ion Channels: Cys-loop Receptors (570)
- Stem cell relevant signaling - JAK/STAT signaling pathway (477)
- Ion Channels: Transient receptor potential (380)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (370)
- Stem cell relevant signaling - Wnt Signaling pathway (294)
- Stem cell relevant signaling - DSL/Notch pathway (291)
- Ion Channels: Glutamate Receptors (277)
- Ion Channels: Calcium (229)
- Ion Channels: Sodium (156)
- Ion Channels: ATP Receptors (137)
- Ion Channels: Cyclic nucleotide gated (81)
- ELISA (49)
- SDS-PAGE (33)
- Bioactivity (24)
- 10 mM Tris-HCl (12)
- the solution can be further dialyzed against PBS (phosphate buffered saline (12)
- Flow Cyt (11)
- 2 mM dithiothreitol (10)
-
ELISA.
Western Blot. (10) - e.g. Dulbecco's PBS). (10)
- Enzyme Activity (9)
- both dissolved in 9.5 M urea buffer (see above). Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl (8)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml (6) - pH 7.4). For immunization purposes (6)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml (4) -
pH 7.4).
For immunization purposes (4) -
pH 7.4).
For immunization purposes (4) - Western Blot. (3)
- 0.1% (w/v) insulin (2)
- 10mM Tris-HCl (2)
- 1mM DTT (2)
- 2 mM dithiothreitol (2)
-
2mM EDTA.
2. Add 4ug of recombinant thioredoxin into reaction cocktail and mix immediately.
3. Incubate at 25°C for 20 minutes.
4. Record the increase in A650nm for 15 minutes (2) - 2mM dithiothreitol (2)
- 63mM sodium phosphate (2)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: After vimentin is dissolved in 9.5M Urea buffer (see above) (2) - Can be used as standard in a Sandwich ELISA. (2)
- FACS (2)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: after desmin is dissolved in 9.5 M urea buffer (see above) (2) -
Protocol: Activity Assay
1. Prepare a 1 ml reaction cocktail into a suitable container: The final concentrations are 5mM Tris (2) - Secreted (2)
-
both dissolved in 9.5 M urea buffer (see above).
Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl (2) - e.g. Dulbeccos PBS). (2)
- e.g.Dulbecco's PBS). (2)
- protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M Urea and then to low salt condition (50mM NaCl (2)
- protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M urea and then to low salt condition (50 mM NaCl (2)
- the solution can be further dialyzed against PBS (Phosphate Buffered Saline (2)
-
ELISA.
Suitable for use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Immunoprecipitation.
Western blotting. (1) -
ELISA.
Western Blot. (1) -
ELISA.
Western blotting. (1) - ELISA. (1)
- Positive control for Western blot analysis (1)
-
Positive control for Western blot analysis.
Standard for ELISA. (1) -
Adermann K. Role of the prosequence of guanylin. Protein Sci. 1999 Sep; 8(9): 1850-9.
4. Lauber T (1) -
Cell culture and/or animal studies.
ELISA.
Western Blot. (1) -
Cohen MB. Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3): G695-702.
3. Schulz A (1) - For use as a Control or Standard in Indirect trapping ELISA for quantitation of antigen in serum using a standard curve (1)
-
For use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Immunoprecipitation.
Western blotting. (1) - Forssmann WG (1)
- Hawkins JA (1)
- Hidaka Y (1)
- Marx UC (1)
-
Marx UC. Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution. Biochemistry. 2002 Dec 10; 41(49): 14602-12.
2. Rudolph JA (1) - Marx UC. Solution structure of human proguanylin: the role of a hormone prosequence. J Biol Chem. 2003 Jun 27; 278(26): 24118-24. Epub 2003 Apr 21. (1)
- Neudecker P (1)
- Nourse A (1)
- Rosch P (1)
- Schulz A (1)
- Shimonishi Y (1)
- Specific methodologies have not been tested using this product. (1)
-
Western Blot.
Protocol: 1. Lauber T (1) - Western Blotting. (1)
- for immunoprecipitation and for Wwestern blotting. (1)
Pathways
- Metabolic pathways (19943)
- Pathways in cancer (9531)
- MAPK signaling pathway (6826)
- Cytokine-cytokine receptor interaction (5529)
- Regulation of actin cytoskeleton (4858)
- Focal adhesion (4576)
- Neuroactive ligand-receptor interaction (4209)
- Endocytosis (4171)
- Chemokine signaling pathway (3963)
- Neurotrophin signaling pathway (3616)
- Insulin signaling pathway (3550)
- Calcium signaling pathway (3485)
- Ubiquitin mediated proteolysis (3450)
- Wnt signaling pathway (3387)
- Jak-STAT signaling pathway (3204)
- Huntington's disease (3145)
- Purine metabolism (3139)
- Natural killer cell mediated cytotoxicity (3091)
- Alzheimer's disease (3043)
- Colorectal cancer (2898)
- Axon guidance (2864)
- Olfactory transduction (2821)
- Tight junction (2808)
- Cell cycle (2797)
- T cell receptor signaling pathway (2772)
- Prostate cancer (2766)
- Progesterone-mediated oocyte maturation (2764)
- Leukocyte transendothelial migration (2717)
- ErbB signaling pathway (2616)
- Cell adhesion molecules (CAMs) (2612)
- Pancreatic cancer (2590)
- Oocyte meiosis (2463)
- Toll-like receptor signaling pathway (2417)
- Apoptosis (2411)
- Melanoma (2350)
- GnRH signaling pathway (2341)
- Lysosome (2284)
- Adherens junction (2280)
- Vascular smooth muscle contraction (2240)
- Hematopoietic cell lineage (2227)
- B cell receptor signaling pathway (2219)
- Melanogenesis (2217)
- Fc gamma R-mediated phagocytosis (2177)
- Fc epsilon RI signaling pathway (2157)
- Chronic myeloid leukemia (2128)
- p53 signaling pathway (2106)
- Endometrial cancer (2100)
- Dilated cardiomyopathy (2067)
- Small cell lung cancer (2054)
- Glioma (2047)
- VEGF signaling pathway (1998)
- Renal cell carcinoma (1977)
- Spliceosome (1974)
- Gap junction (1953)
- Hypertrophic cardiomyopathy (HCM) (1902)
- Parkinson's disease (1876)
- Systemic lupus erythematosus (1833)
- Pyrimidine metabolism (1805)
- Acute myeloid leukemia (1755)
- Non-small cell lung cancer (1755)
- Oxidative phosphorylation (1750)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (1720)
- Long-term potentiation (1716)
- TGF-beta signaling pathway (1698)
- mTOR signaling pathway (1664)
- Adipocytokine signaling pathway (1647)
- Long-term depression (1644)
- Glycolysis / Gluconeogenesis (1608)
- PPAR signaling pathway (1601)
- Antigen processing and presentation (1583)
- Bladder cancer (1530)
- RIG-I-like receptor signaling pathway (1521)
- NOD-like receptor signaling pathway (1520)
- Phosphatidylinositol signaling system (1516)
- Type II diabetes mellitus (1472)
- Epithelial cell signaling in Helicobacter pylori infection (1469)
- Viral myocarditis (1465)
- Complement and coagulation cascades (1416)
- Thyroid cancer (1415)
- Amyotrophic lateral sclerosis (ALS) (1398)
- ECM-receptor interaction (1351)
- Cardiac muscle contraction (1303)
- Pathogenic Escherichia coli infection (1279)
- Ribosome (1245)
- Glycerophospholipid metabolism (1243)
- Drug metabolism - cytochrome P450 (1194)
- Metabolism of xenobiotics by cytochrome P450 (1180)
- Amino sugar and nucleotide sugar metabolism (1178)
- Basal cell carcinoma (1146)
- Cytosolic DNA-sensing pathway (1146)
- Vibrio cholerae infection (1135)
- Inositol phosphate metabolism (1131)
- Starch and sucrose metabolism (1118)
- Arginine and proline metabolism (1102)
- Primary immunodeficiency (1046)
- Mismatch repair (972)
- Valine (972)
- Hedgehog signaling pathway (971)
- Retinol metabolism (970)
- Drug metabolism - other enzymes (964)
- Glutathione metabolism (964)
- RNA degradation (947)
- Notch signaling pathway (900)
- Arachidonic acid metabolism (898)
- Autoimmune thyroid disease (891)
- Tyrosine metabolism (852)
- leucine and isoleucine degradation (832)
- Pyruvate metabolism (829)
- Type I diabetes mellitus (825)
- Fatty acid metabolism (807)
- Nucleotide excision repair (807)
- Glycerolipid metabolism (804)
- Galactose metabolism (798)
- Proteasome (798)
- Lysine degradation (754)
- Homologous recombination (750)
- Taste transduction (748)
- Tryptophan metabolism (748)
- Sphingolipid metabolism (742)
- Prion diseases (741)
- Maturity onset diabetes of the young (739)
- Cysteine and methionine metabolism (721)
- Graft-versus-host disease (711)
- Fructose and mannose metabolism (710)
- N-Glycan biosynthesis (710)
- Base excision repair (705)
- Dorso-ventral axis formation (698)
- Citrate cycle (TCA cycle) (691)
- Alanine (675)
- aspartate and glutamate metabolism (675)
- Allograft rejection (667)
- Androgen and estrogen metabolism (641)
- Porphyrin and chlorophyll metabolism (641)
- SNARE interactions in vesicular transport (626)
- Propanoate metabolism (598)
- DNA replication (586)
- Regulation of autophagy (584)
- Butanoate metabolism (581)
- Aminoacyl-tRNA biosynthesis (580)
- Ether lipid metabolism (571)
- Pentose phosphate pathway (570)
- Nitrogen metabolism (551)
- Histidine metabolism (543)
- Glycine (540)
- serine and threonine metabolism (540)
- ABC transporters (539)
- Glycosphingolipid biosynthesis - lacto and neolacto series (531)
- Selenoamino acid metabolism (501)
- Basal transcription factors (471)
- Asthma (456)
- Linoleic acid metabolism (451)
- Glycosaminoglycan degradation (442)
- RNA polymerase (438)
- Nicotinate and nicotinamide metabolism (436)
- Phenylalanine metabolism (429)
- O-Glycan biosynthesis (418)
- beta-Alanine metabolism (416)
- Pentose and glucuronate interconversions (388)
- Pantothenate and CoA biosynthesis (357)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (348)
- Riboflavin metabolism (342)
- Ascorbate and aldarate metabolism (341)
- One carbon pool by folate (335)
- Sulfur metabolism (335)
- Primary bile acid biosynthesis (332)
- Renin-angiotensin system (329)
- Biosynthesis of unsaturated fatty acids (326)
- Other glycan degradation (322)
- Heparan sulfate biosynthesis (320)
- Keratan sulfate biosynthesis (313)
- Terpenoid backbone biosynthesis (296)
- Glyoxylate and dicarboxylate metabolism (293)
- alpha-Linolenic acid metabolism (291)
- Steroid biosynthesis (285)
- Glycosphingolipid biosynthesis - globo series (271)
- Chondroitin sulfate biosynthesis (263)
- Non-homologous end-joining (255)
- Limonene and pinene degradation (237)
- Circadian rhythm - mammal (234)
- Glycosphingolipid biosynthesis - ganglio series (234)
- C21-Steroid hormone metabolism (215)
- leucine and isoleucine biosynthesis (212)
- Taurine and hypotaurine metabolism (210)
- Folate biosynthesis (205)
- Cyanoamino acid metabolism (183)
- Thiamine metabolism (176)
- Protein export (173)
- Caffeine metabolism (155)
- Synthesis and degradation of ketone bodies (150)
- Fatty acid elongation in mitochondria (137)
- Methane metabolism (130)
- Ubiquinone and other terpenoid-quinone biosynthesis (112)
- Fatty acid biosynthesis (95)
- Phenylalanine (78)
- tyrosine and tryptophan biosynthesis (78)
- Lysine biosynthesis (77)
- Lipoic acid metabolism (70)
- Vitamin B6 metabolism (69)
- D-Glutamine and D-glutamate metabolism (65)
- O-Mannosyl glycan biosynthesis (60)
- Biotin metabolism (44)
- D-Arginine and D-ornithine metabolism (15)