RXR-alpha / RXRA (111-228) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
Predicted MW	13.6 kDa
Concentration	lot specific
Purity	>95% by SDS-PAGE
Buffer	Presentation State: Purified State: Liquid protein Buffer System: 20 mM Tris-HCl pH 7.5, 0.1 M NaCl, 5 mM beta-Mercaptoethanol
Preparation	Liquid protein
Protein Description	The DNA binding domain of RXR (111-228 aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.
Storage	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001278849
Locus ID	6256
UniProt ID	A0A5F9ZHH6, Q6P3U7
Cytogenetics	9q34.2
Synonyms	NR2B1
Summary	Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways	Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer

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