Pirh2 (RCHY1) (NM_015436) Human Mass Spec Standard

Specifications

Product Data
Description	RCHY1 MS Standard C13 and N15-labeled recombinant protein (NP_056251)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC207970
Predicted MW	30.1 kDa
Protein Sequence	Sequence Link (showhide) >RC207970 protein sequence Red=Cloning site Green=Tags(s) MAATAREDGASGQERGQRGCEHYDRGCLLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQH AQQTCEECSTLFGEYYCDICHLFDKDKKQYHCENCGICRIGPKEDFFHCLKCNLCLAMNLQGRHKCIENV SQQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDDEVAQTPMP SEYQNMTVDILCNDCNGRSTVQFHILGMKCKICESYNTAQAGGRRISLDQQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_056251
RefSeq Size	4447
RefSeq ORF	783
Synonyms	ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Locus ID	25898
Cytogenetics	4q21.1
Summary	The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	p53 signaling pathway, Ubiquitin mediated proteolysis

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