United States
Germany
Japan
United Kingdom
China
BCAR1 (NM_001170714) Human Untagged Clone
CAT＃: SC329220
BCAR1 (untagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1) transcript variant 1
CNY 17,580.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAS; CAS1; CASS1; CRKAS; P130Cas |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001170714, the custom clone sequence may differ by one or more nucleotides
ATGCCTGCCAAGCCCTTCCTCTCTTCTGTTCTGCTCTCCTGGAAAGTTCTGGACTTCTCT GGCCCAGGGCCTCAGGGGACTGGCCAGCCCTGCTCCTGTGGGCACTGGGCAGAGGGACAA GGCGGACCACCTGAGCCTGCTGGAGGGCCGAACGTGCTGGCCAAAGCGCTCTATGACAAT GTGGCCGAGTCCCCGGATGAGCTCTCCTTCCGCAAGGGTGACATCATGACGGTGCTGGAG CAGGACACGCAGGGCCTGGACGGCTGGTGGCTCTGCTCGCTGCATGGGCGCCAGGGCATC GTGCCTGGGAACCGCCTCAAGATCTTGGTGGGCATGTATGATAAGAAGCCAGCAGGGCCT GGCCCCGGCCCTCCCGCCACCCCGGCCCAGCCTCAGCCTGGCCTCCATGCCCCAGCGCCT CCGGCCTCCCAGTACACGCCCATGCTCCCCAACACCTACCAGCCCCAGCCAGACAGCGTC TACCTGGTGCCCACTCCCAGCAAGGCTCAGCAAGGCCTCTACCAAGTCCCGGGTCCCAGC CCTCAGTTCCAGTCTCCCCCAGCCAAGCAGACATCCACCTTCTCGAAGCAGACACCCCAT CACCCGTTTCCCAGCCCGGCCACAGACCTGTACCAGGTGCCCCCAGGGCCTGGAGGCCCT GCCCAGGATATTTACCAGGTGCCACCTTCTGCCGGGATGGGGCATGACATCTACCAGGTC CCCCCGTCCATGGACACACGCAGCTGGGAGGGCACGAAGCCCCCGGCAAAGGTGGTGGTG CCCACCCGCGTGGGGCAGGGCTATGTATACGAGGCCGCCCAGCCGGAGCAGGACGAGTAC GACATCCCGCGACACCTGCTGGCCCCGGGGCCACAGGACATCTATGATGTGCCCCCGGTT CGGGGGCTGCTTCCCAGCCAGTATGGCCAGGAGGTGTATGACACACCCCCCATGGCTGTC AAGGGTCCCAATGGCCGAGACCCGTTGCTGGAGGTGTATGACGTGCCCCCCAGTGTGGAG AAGGGCCTGCCACCGTCCAACCACCACGCAGTCTACGACGTTCCTCCATCGGTGAGCAAG GATGTGCCCGATGGCCCACTGCTGCGTGAGGAGACCTACGATGTGCCCCCCGCCTTCGCC AAGGCCAAGCCCTTTGACCCGGCCCGCACCCCACTGGTACTGGCTGCGCCCCCTCCAGAC TCCCCGCCGGCCGAGGACGTGTATGACGTGCCGCCCCCGGCTCCTGACCTCTACGACGTG CCCCCTGGCTTGCGGCGGCCTGGCCCGGGCACCCTGTACGATGTGCCCCGTGAACGGGTG CTTCCTCCTGAGGTGGCTGATGGTGGCGTGGTCGACAGTGGTGTGTATGCGGTGCCTCCC CCAGCTGAACGTGAAGCCCCGGCAGAGGGCAAGCGCCTGTCGGCCTCCAGCACCGGCAGC ACACGCAGCAGCCAGTCTGCGTCCTCCTTGGAGGTGGCAGGGCCGGGCCGGGAACCCCTG GAGCTGGAAGTTGCTGTGGAGGCCCTGGCACGGCTGCAGCAGGGTGTGAGCGCCACCGTT GCCCACCTTCTGGACCTGGCAGGCAGCGCCGGTGCGACTGGGAGCTGGCGTAGCCCCTCT GAGCCACAGGAGCCGCTGGTGCAGGACCTGCAGGCTGCTGTGGCCGCTGTCCAGAGTGCC GTCCACGAGCTGTTGGAGTTTGCCCGCAGCGCGGTGGGCAATGCTGCCCACACATCTGAC CGTGCCCTGCATGCCAAGCTTAGCCGGCAGCTGCAGAAGATGGAGGACGTGCACCAGACG CTGGTGGCACATGGTCAGGCCCTCGACGCTGGCCGGGGAGGCTCTGGAGCCACCCTTGAG GACCTGGACCGGCTGGTGGCCTGCTCGCGGGCTGTGCCCGAGGACGCCAAGCAGCTGGCC TCCTTCCTGCACGGCAATGCCTCACTGCTCTTCAGACGGACCAAGGCCACTGCCCCGGGG CCTGAGGGGGGTGGCACCCTGCACCCCAACCCCACTGACAAGACCAGCAGCATCCAGTCA CGACCCCTGCCCTCACCCCCTAAGTTCACCTCCCAGGACTCGCCAGATGGGCAGTACGAG AACAGCGAGGGGGGCTGGATGGAGGACTATGACTACGTCCACCTACAGGGGAAGGAGGAG TTTGAGAAGACCCAGAAGGAGCTGCTGGAAAAGGGCAGCATCACGCGGCAGGGCAAGAGC CAGCTGGAGTTGCAGCAGCTGAAGCAGTTTGAACGACTGGAACAGGAGGTGTCACGGCCC ATAGACCACGACCTGGCCAACTGGACGCCAGCCCAACCCCTGGCCCCGGGGCGAACAGGC GGCCTGGGGCCCTCGGACCGGCAGCTGCTGCTCTTCTACCTGGAGCAGTGTGAGGCCAAC CTGACCACACTGACCAACGCCGTGGACGCCTTCTTTACCGCCGTGGCCACCAACCAGCCG CCCAAGATCTTTGTGGCGCACAGCAAGTTCGTCATCCTCAGCGCCCACAAGCTGGTGTTC ATCGGGGACACACTGTCACGGCAGGCCAAGGCTGCTGACGTGCGCAGCCAGGTGACCCAC TACAGCAACCTGCTGTGCGACCTCCTGCGCGGCATCGTGGCCACCACCAAGGCCGCTGCC TTGCAGTACCCATCGCCTTCCGCGGCCCAGGACATGGTGGAGAGGGTCAAGGAGCTGGGC CACAGCACCCAGCAGTTCCGCCGCGTCCTAGGCCAGCTGGCAGCCGCCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001170714 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001170714.1, NP_001164185.1 |
| RefSeq Size | 3533 bp |
| RefSeq ORF | 2751 bp |
| Locus ID | 9564 |
| UniProt ID | P56945 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
| Gene Summary | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC230582 | BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 1 |
CNY 9,600.00 |
|
| RC230582L3 | Lenti-ORF clone of BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 1 |
CNY 11,500.00 |
|
| RC230582L4 | Lenti-ORF clone of BCAR1 (mGFP-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 1 |
CNY 11,500.00 |
|
| RG230582 | BCAR1 (tGFP-tagged) - Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 1 |
CNY 10,550.00 |
