Histone H2A.X (H2AFX) Rabbit Polyclonal Antibody

CAT#: TA347131

Rabbit Polyclonal H2A.XS139p Antibody



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CNY 6,098.00


货期*
5周

规格
    • 50 ug

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    • 100 ug

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Specifications

Product Data
Applications Dot, ELISA, WB
Recommend Dilution ELISA (1:10,000); Dot blotting (1:10,000); Western blotting (1:1,000)
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen The immunogen for anti-H2A.XS139p antibody: the region of histone H2A.X containing the phosphorylated serine 139 (H2A.XS139p), using a KLH-conjugated synthetic peptide.
Concentration lot specific
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name H2A histone family member X
Background Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. H2A.XS139p appears during apoptosis and is probably involved in DNA repair.
Synonyms H2A; H2A.X; H2AX; X
Reference Data
Protein Families Druggable Genome
Protein Pathways Systemic lupus erythematosus
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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