LRRK2 (1-500) Mouse Monoclonal Antibody [Clone ID: S138-6]

CAT#: AM60066PU-N

LRRK2 (1-500) mouse monoclonal antibody, clone S138-6, Purified



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CNY 5,830.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name S138-6
Applications IF, WB
Recommend Dilution Western blot: 1/1000; 1 μg/ml was sufficient for detection of PARK8 / LARRK2 in 20 μg of rat brain lysate by colorimetric immunoblot using HRP conjugated secondary antibody.
Immunocytochemistry.
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Fusion protein amino acids 1-500 (N-terminus) of human PARK8 / LRRK2. No significant identity with LRRK1.
Specificity This antibody detects a > 200 kDa protein corresponding to the molecular weight of PARK8 / LARRK2.
Formulation PBS pH 7.4, 50% Glycerol, 0,09% Sodium azide
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Protein G chromatography
Conjugation Unconjugated
Storage Condition Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name leucine-rich repeat kinase 2
Background PARK8 / LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
Synonyms Dardarin
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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