CD11b (ITGAM) Mouse Monoclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human CD11B (630aa-1104aa).
Specificity	CD11B (L1) mAb detects endogenous levels of CD11B protein.
Isotype	IgG
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 170 kDa
Gene Name	integrin subunit alpha M
Database Link	Entrez Gene 3684 Human UniProt ID P11215
Background	Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Synonyms	CD11 antigen-like family member B; CD11B; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; CR-3α; CR3A; CR3α; Integrin alpha-M; Integrin αM; ITGAM; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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