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OriGene shRNA Recent Citations

RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency, Human Gene Therapy. August 2008, 19(8): 763-773 [sh-Luc(in vivo application)]

Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis, Koji Taniguchi, Ken-ichiro Sasaki, Kousuke Watari, Hideo Yasukawa, Tsutomu Imaizumi, Toranoshin Ayada, Fuyuki Okamoto, Takuma Ishizaki,Reiko Kato,Ri-ichiro Kohno,Hiroshi Kimura,Yasufumi Sato,Mayumi Ono,Yoshikazu Yonemitsu,and Akihiko Yoshimura, PLoS ONE. 2009; 4(5): e5467 [Spry4(in vivo application)]

MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge, J. Immunol., Aug 2009; 183: 1617 - 1624 [CISH]

[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase, Cancer Res., Jul 2009; 69: 5584 - 5591 [LTA4H]

Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4, Cancer Res., Jul 2009; 69: 5743 - 5751. [RGS4]

DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair, Mol. Cell. Biol., Jul 2009; 29: 3597 - 3604 [TRF2]

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK, Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 [RALa]

All Citations click here


Mouse Monoclonal Antibody Development

Human Proteins as Antigens
(TrueMAB?joint-development program for human proteome)
High Quality Antibodies Start from Antigens with Native Conformations. OriGene handles antigen preparation and provides its human protein collection for immunization. The antigen will be expressed in human HEK293T cell line and purified under native conditions with affinity chromatography to preserve native protein structures with genuine mammalian post-translational modifications. Antigens preserved protein native conformation consist of native epitopes, which result in antibodies with high specificity and reactivity. In comparison to peptide-derived antibodies, these antibodies provide exceptional performances for the immunoassays that are sensitive to protein conformation, such as immunofluorescence, immunoprecipitation, ELISA, antibody array, immunohisotchemistry and flow cytometry.
  • - Balb/c mice immunization and boosting with ELISA screening
  • - Splenocyte fusion and expansion with ELISA screening
  • - Subcloning and stabilization of positive clones with ELISA screening
Extensive Validation is Critical to Generate Monoclonal Antibodies with High Reactivity for Specific Immunoassays. OriGene provides validation data for derived monoclonal antibodies at no extra cost, including:
  • - Western blot on OriGene overexpression cell lysate (in human cell lines)
  • - Western blot on a panel of at least 7 different cell lines
  • - IHC on up to 18 unique normal and disease-state FFPE human tissues
  • - Immunofluorescent staining on a human cell line with the over-expressed antigen
  • - Immunofluorescent staining on native cell lines
  • - ELISA using recombinant proteins generated by human cell lines
Antibodies Derived from All Clones are Available for Selection. OriGene will post antibody validation data of all available clones for antibody selection.
Deliver Purified Monoclonal Antibodies Ready for Your Immunoassays. OriGene will deliver aggregated total of 6 mg (1 mg per vial) of affinity purified monoclonal antibodies from your selection of 1-3 clones. Additional antibodies can be purchased at the time of delivery at ¥2375 per mg up to 5 mg. Future purchases of the antibodies related to the project will be under OriGene抯 catalog offering. Hybridomas are not included under program fee. Hybridoma cells can be purchased under separate licensing agreement.
How was the program fee determined?
  • OriGene subsidizes part of the monoclonal antibody development cost. OriGene抯 long-term goal is to provide high quality monoclonal antibodies covering the entire human proteome.
  • OriGene is sharing its valuable resources of
    • over 5,000 purified human proteins
    • over 25,000 full length human cDNA clones
Program Terms & Conditions
  • ¥2375 non-refundable set-up fee required upon the acceptance and initiation of the projects.
  • Participants agree to cite OriGene as the source of the monoclonal antibodies in all publications and public communications
  • Frozen hybridoma cells are not included under the program fee. OriGene retains ownership and the rights to the commercialization of the derived hybridomas and antibodies. Hybridoma cells can be purchased under separate licensing agreement. Future purchases of the antibodies related to the project will be under OriGene抯 catalog offering.
  • The derived antibodies shall only be used for research purposes. The resale of the derived antibodies, or any unmodified derivatives and parts thereof, is strictly prohibited. Participants shall only have a non-transferable right to use the derived antibodies.

TrueMAB?Program Details

Monoclonal antibodies for every human protein

For further questions, please contact OriGene at antibody@origene.com.


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